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| 1950 SCHEDULEOverall 4-4-1Home 2-2Away 1-2-1Neutral 1-0 |
| Date | Opponent / Event | Location | Time / Result | Media | |
| Sat., Sep. 30 | vs. North Carolina |
Notre Dame, Ind. | W, 14-7 | More | |
| Sat., Oct. 7 | vs. Purdue |
Notre Dame, Ind. | L, 28-14 | More | |
| Sat., Oct. 14 | at Tulane |
New Orleans, La. | W, 13-9 | More | |
| Sat., Oct. 21 | at Indiana |
Bloomington, Ind. | L, 20-7 | More | |
| Sat., Oct. 28 | vs. Michigan State |
Notre Dame, Ind. | L, 36-33 | More | |
| Sat., Nov. 4 | vs. Navy |
Cleveland, Ohio | W, 19-10 | More | |
| Sat., Nov. 11 | vs. Pittsburgh |
Notre Dame, Ind. | W, 18-7 | More | |
| Sat., Nov. 18 | at Iowa |
Iowa City, Iowa | T, 14-14 | More | |
| Sat., Dec. 2 | at USC |
Los Angeles, Calif. | L, 9-7 | More | |
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