Friday | March 25 | 9:00 p.m. ET | 
Rupp Arena | Lexingon, Ky. | Sweet 16 
#1 Notre Dame Fighting Irish33-2 (16-0, 1st ACC) – ACC Champion
- Coach: Muffet McGraw (1 title, 7 Final Fours)
- Key Wins: Ore. St., Ohio St., UCLA, Syracuse (2), Louisville, Fla. St.
- Record vs. RPI Top 50: 15-1
- NCAA Record: 56-22 (23rd Appearance)
- Last Appearance: NCAA Runner-Up (2015)
- Best Finish: NCAA Champion (2001)
Stanford Cardinal27-7 (14-4, T-3rd PAC-12) – At-Large
- Coach: Tara VanDerveer (2 titles, 11 Final Fours)
- Key Wins: Ore. St., George Washington, Tennessee
- Record vs. RPI Top 50: 5-6
- NCAA Record: 80-27 (30th Appearance)
- Last Appearance: Sweet 16 (2015)
- Best Finish: NCAA Champion (1990, 1992)